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Four headshots of winnners of the 2024 Karches Prize - Shandon Amos, Christina Cabana, Ivan Pires, and Jason Yu.

Introducing the 2024 Karches Prize winners

Congratulations to the winners of the 2024 Peter Karches Mentorship Prize — Shandon Amos, Christina Cabana, Ivan Pires, and Jason Yu.

The Peter Karches Mentorship Prize is awarded annually to up to four Koch Institute postdocs, graduate students or research technicians who demonstrate exemplary mentorship of undergraduate researchers or high school students in their labs. The prize allows the Koch Institute community to celebrate and recognize the critical role that mentors play, both personally and professionally, in the early stages of a scientist’s career.

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10 Years of the Bridge Project

MIT Koch Institute

In large part the brainchild of the late Art Gelb, ScD ’61, the Bridge Project was launched in 2012 with a simple idea uniquely suited to Greater Boston. Designed to leverage the collective expertise of MIT and Harvard, particularly its clinical cancer centers and teaching hospitals, the program’s goal is to enable collaborative research teams combining innovative science, tools and technologies with the translational expertise of clinical oncologists to solve challenging problems in cancer.  

Transformations in Cancer Care

Washington Post Live

Although cancer mortality rates have declined overall, roughly 2 million people will be diagnosed with cancer and 600,000 Americans will die from the disease this year. Robert Weinberg talks to Washington Post Live about the state of cancer research and how technological advancements are transforming cancer detection and treatment. 

Moving the Needle on Appendiceal Cancer

MIT Koch Institute

Co-hosted by MIT’s Laboratory for Financial Engineering and Koch Institute for Integrative Cancer Research, the workshop “New Approaches to Accelerating Biomedical Innovation: Case Study on Appendiceal Cancer” brought together stakeholders across academia, industry, patient advocacy groups, and regulatory spaces to lay a foundation for accelerating the development of new treatments for cancer of the appendix—a disease with few effective treatments and a low survival rate.

Anchors Aweigh for Immunotherapy Translation

Business Wire

An approach engineered in the Irvine and Wittrup labs to anchor powerful immune medicines at the tumor site—thus avoiding challenges of both systemic and intratumoral delivery—is headed to trials. Ankyra Therapeutics, which the researchers co-founded, announced approval of its investigational new drug application by the US FDA and clinical trial application by Health Canada for its lead agent, ANK-101. Watch or read more to learn about the original research, supported in part by the Marble Center for Cancer Nanomedicine, the Hope Babette Tang (1983) Student Research Fund, the Kristin R. Pressman and Jessica J. Pourian (2013) Koch Institute Fund, the Charles S. Krakauer (1954) Fund, and a KI Quinquennial Cancer Research Fellowship.
 

How to Succeed at Failing

Freakonomics Podcast

“Was that really failure? Or was it just being an apprentice to trying to learn how to succeed?”  Robert Langer interviews with the Freakonomics podcast in their multipart series, “How to Succeed at Failing.”

Congratulations, Tigist!

Fred Hutch Cancer Center

Congratulations to White Lab postdoc Tigist Tamir on winning one of the Fred Hutch Cancer Center's 2023 Dr. Eddie Méndez Scholar Awards! The award recognizes early-career underrepresented minority scientists and scientists with disabilities.  

KI Trio elected to National Academy of Medicine

MIT News

Daniel Anderson, Darrell Irvine and Regina Barzilay have been elected to the National Academy of Medicine! Weinberg Lab alumnus and cancer researcher Siddhartha Mukherjee, whose best-seller Emperor of All Maladies highlighted breakthroughs made by MIT’s cancer research community, was also recognized. Election to the academy is one of the highest honors in the fields of health and medicine, recognizing outstanding professional achievement and commitment to service. Congratulations to all!

Circular RNA Round-Up

Nature

Nature rounds up everything you need to know about circular RNA, including advances from the Anderson Lab and its spinout Orna Therapeutics. By tying ends of RNA together, circular RNA can stick around longer than the linear RNA currently used in vaccines and other therapies.

Moungi Bawendi wins 2023 Nobel Prize in Chemistry

MIT News

Congratulations to Moungi Bawendi, the Lester Wolfe Professor of Chemistry, on winning the 2023 Nobel Prize in Chemistry! Bawendi shares the prize with Louis Brus of Columbia University and Alexei Ekimov of Nanocrystals Technology for pioneering the development of quantum dots. These semiconducting nanocrystals emit exceptionally pure light and have been deployed in computer and television displays and biomedical imaging. Bawendi has collaborated with Koch Institute member Linda Griffith and former administrator W. David Lee ’69 on the Lumicell Imaging System, a low-cost single-cell imaging technology for eliminating residual cancer cells during tumor resection. Supported in its early stages of development by the Koch Institute Frontier Research Program through the Kathy and Curt Marble Cancer Research Fund, the system was pairs an injectable contrast agent with a hand-held, single-cell resolution imager to scan surgical margins for residual cancer cells. The system is now on the fast track to FDA approval, and could help eliminate the need for repeat cancer surgeries, reduce the incidence of relapse, and lower healthcare costs.

Targeting Titans of Transcription

MIT News

A signature technology from Angela Koehler is a low-cost screening tool for studying how transcription factors—proteins that regulate gene expression—interact with each other, and identifying compounds that modulate them. Beyond her lab, the platform contributes to translational work in her startup, Kronos Bio, which is now conducting clinical trials targeting MYC, a transcription factor whose dysregulation helps drive multiple cancers.